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The Liver has Over 500 Functions. Could it Be the Key to Solving Your Health Problem?

posted on 26 March 2009 | posted in Health Articles


Toxins are widespread in the modern environment and are known to cause numerous health problems.

For example they are implicated in causing: acne, allergies, alopecia, anaemia, arthritis, asthma, ataxia, atherosclerosis, autoimmune disease (specifically rheumatoid arthritis, lupus erythematosus, myasthenia gravis, diabetes, thyroiditis), bronchitis, cancer, cellulite, chronic flu-like symptoms, chronic fatigue, constipation, criminal behaviour, Crohn's disease, depression, dermatitis, diarrhoea, dizziness, eczema, emphysema, gastroenteritis, headaches, hyperactivity/learning disability, immune disorders, indigestion, inflammatory conditions, kidney disease, liver disease, mental confusion, mental disease, multiple chemical sensitivity, muscle pains/weakness, nausea, pancreatitis, Parkinson's disease, poor co-ordination, premature aging, psoriasis, senile dementia, stuffy nose, tingling in extremities, tinnitus, tremors, ulcerative colitis and watering eyes.

Indeed the ability to detoxify and eliminate toxins largely determines an individuals health status. Little wonder that many naturopaths advocate a periodic bodily spring clean, just as they do a periodic parasite cleanse.

Toxins may be classified as follows: xenobiotics (pollutants, drugs), heavy metals, toxic food constituents, microbial-dervied toxins, toxins derived from pathological processes, and waste from physiological processes.

These are all detoxified (i.e. rendered harmless or excretable) principally in the liver by a two-step process:

Phase 1 detoxification

(Mainly hydroxylation by mono-oxygenase enzymes, principally cytochrome P-450 species)

Phase 2 detoxification

A: Conjugation reactions
  • Glucuronidation
  • Sulphation
  • Glutathione conjugation
  • Amino acid conjugation (chiefly with glycine, but also taurine, glutamine, arginine and ornithine

    B: Sulphoxidation
    C: Methylation
    D: Acetylation

    The efficiency of liver detoxification varies widely between individuals (up to five-fold differences have been observed). Fortunately sub-optimal liver detoxification can be improved by dietary measures, nutritional supplements and herbs. Broccoli Plus Formula belongs to the latter category and contains dill, caraway, broccoli and milk thistle.

    Dill and Caraway - these herbs contain limonene, which is a strong inducer of both phase 1 & phase 2 (glutathione conjugation, glucuronidation) detoxification pathways. We have seen these herbs rapidly restore a dogs vigour after failure to recover from the sedative effects of diazepam.

    Broccoli - raw broccoli is a veritable treasure trove of nutrients, providing quercetin, alpha-lipoic acid, glutathione, beta carotene, lutein, vitamin c, chromium, sulphur, glucarate, sulphoraphane, indoles and fibre.
    Sulphoraphane greatly stimulates the activity of several key detoxifying enzymes including phase 1 enzymes and glutathione conjugation, glucuronidation and sulphation. The broccoli used in detoxrejuve is standardized with regard to its sulphoraphane content.

    Milk Thistle - this herb is renowned for its liver tonifying effects. Milk thistle contains a mixture of bioflavonoids called silymarin, which have been shown to increase the glutathione level in the liver by up to 35%. Not only is glutathione extremely important in enabling liver detoxification, it is the most important antioxidant for the purposes of neutralizing the damaging free radicals that are inevitably produced during phase 1 detoxification.

    If nutritional support for liver detoxification is required, the following nutrients can be used:
  • Vitamin C
  • Magnesium
    zinc, copper, vitamin B2, vitamin B3 (phase 1); magnesium (glucuronidation); cysteine and other sulphur-containing amino acids, Sulphur(sulphation; glutathione, glycine, cysteine, glutamine, lipoic acid, vitamin C, vitamin B2, vitamin B6, selenium, (glutathione conjugation); glycine, taurine, glutamine, arginine, ornithine (amino acid conjugation); Molybdenum(sulphoxidation); methionine, vitamin B6, folic acid, choline (methylation); vitamin B2, vitamin B5, vitamin C (acetylation).

    We suggest you take a high potency vitamin and mineral formula containing all these nutrients. The one that contains all of the above that we use is Arterial Health (ignore the name of this - it is a general formula that any adult can use) take 4 tablets daily for a really good all round supplement. For the amino acids take SynerProTein. It is really important to get a good source of protein as this is broken down into amino acids needed for healthy detoxification.

    A diet high in fibre is really important (fibre binds intestinal toxins). If you are not eating 30g of fibre a day you may need to take some extra fibre.

    Sarsaparilla (sarsaparilla saponins bind intestinal bacterial endotoxins) and probiotics like: Bifido-acidophilus (25% of the detoxification that occurs in the body is believed to occur in the gut, and is mediated by intestinal bacteria, which possess a P-450 enzyme system.

    Lack of exercise is a big component when it comes to poor liver function. The best exercise we recommend that can be done by anyone is rebounding. Rebounding only takes a few minutes a day and really gets the lymphatic system working properly. You can start to feel better in a few days!



     


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